GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs73726531 | 1 | rs79325856 | chr6:18161232 | NHLRC1 | chr6:18120718-18122851:- | -1 | -4.28 | 4.46E-5 | Thiopurine S-methyltransferase activity |
| THYM | cis | rs11723261 | 1 | rs79366248 | chr4:266659 | ZNF718 | chr4:53272-156488:+ | 0.65 | 7.31 | 8.46E-11 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs7937 | 1 | rs7937 | chr19:41302706 | RAB4B | chr19:41281657-41302847:+ | -0.2 | -4.52 | 1.76E-5 | Post bronchodilator FEV1;Emphysema imaging phenotypes;Chronic obstructive pulmonary disease;Post bronchodilator FEV1/FVC ratio |
| THYM | cis | rs2143950 | 1 | rs79436302 | chr14:35578797 | KIAA0391 | chr14:35591776-35786673:+ | 0.32 | 4.14 | 7.59E-5 | Atopic dermatitis |
| THYM | cis | rs2143950 | 1 | rs79436302 | chr14:35578797 | PPP2R3C | chr14:35554679-35591679:- | 0.27 | 4.99 | 2.76E-6 | Atopic dermatitis |
| THYM | cis | rs7944004 | 1 | rs7944004 | chr11:2311152 | C11orf21 | chr11:2317507-2323143:- | 0.36 | 5.02 | 2.44E-6 | Chronic lymphocytic leukemia |
| THYM | cis | rs2077224 | 1 | rs7944436 | chr11:62200661 | ASRGL1 | chr11:62104774-62160885:+ | -0.3 | -4.15 | 7.28E-5 | Chronic obstructive pulmonary disease-related biomarkers |
| THYM | cis | rs9815354 | 1 | rs79548696 | chr3:41803385 | ULK4 | chr3:41288091-42003660:- | 0.99 | 10.49 | 1.47E-17 | Diastolic blood pressure |
| THYM | cis | rs7969151 | 1 | rs7968810 | chr12:54158993 | COPZ1 | chr12:54718911-54745633:+ | -0.3 | -4.79 | 6.15E-6 | Tanning |
| THYM | cis | rs7969151 | 1 | rs7968870 | chr12:54159249 | COPZ1 | chr12:54718911-54745633:+ | 0.29 | 4.6 | 1.33E-5 | Tanning |
| THYM | cis | rs7969151 | 1 | rs7969151 | chr12:54159277 | COPZ1 | chr12:54718911-54745633:+ | -0.3 | -4.79 | 6.15E-6 | Tanning |
| THYM | cis | rs2143950 | 1 | rs79702597 | chr14:35558856 | KIAA0391 | chr14:35591776-35786673:+ | 0.32 | 4.16 | 6.96E-5 | Atopic dermatitis |
| THYM | cis | rs2143950 | 1 | rs79702597 | chr14:35558856 | PPP2R3C | chr14:35554679-35591679:- | 0.27 | 5.01 | 2.56E-6 | Atopic dermatitis |
| THYM | cis | rs60843830 | 1 | rs79716074 | chr2:277003 | SH3YL1 | chr2:218138-264810:- | -0.33 | -4.86 | 4.59E-6 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs2143950 | 1 | rs79888893 | chr14:35510676 | PPP2R3C | chr14:35554679-35591679:- | 0.27 | 5.01 | 2.49E-6 | Atopic dermatitis |